B. longum

B. longum:

• Abundance associated with higher bacterial gene richness in the gut • Abundance decreases with weight loss • Found Increased in obese subjects compared to lean/overweight

Source: https://www.gdx.net/core/interpretive-guides/GI-Effects-IG.pdf

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Ruminococcus

Ruminococcus:

• Abundance associated with low bacterial gene richness in the gut • Human studies have reported that Ruminococcus spp. tend to be more abundant in IBD; active UC, active CD, and ileal CD • Levels are variable in IBS, depending on IBS subtype, with some researchers reporting increased concentrations and some finding decreased amounts • May be more prevalent in autism

Source: https://www.gdx.net/core/interpretive-guides/GI-Effects-IG.pdf

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Lactobacillus spp.

Lactobacillus spp.:

• Abundance associated with higher bacterial gene richness in the gut • Studies have reported altered levels in IBS, with some finding higher concentrations and others finding lower concentrations • Lower levels reported to correlate with symptom severity in IBS • Increased levels seen in obese patients compared to lean controls

Source: https://www.gdx.net/core/interpretive-guides/GI-Effects-IG.pdf

“Overall, both of these microbes seem to be major players in the gut-brain axis. John Cryan, a neuroscientist at the University College of Cork in Ireland, has examined the effects of both of them on depression in animals. In a 2010 paper published in Neuroscience, he gave mice either bifidobacterium or the antidepressant Lexapro; he then subjected them to a series of stressful situations, including a test which measured how long they continued to swim in a tank of water with no way out. (They were pulled out after a short period of time, before they drowned.) The microbe and the drug were both effective at increasing the animals’ perseverance, and reducing levels of hormones linked to stress. Another experiment, this time using lactobacillus, had similar results. Cryan is launching a study with humans (using measurements other than the forced swim test to gauge subjects’ response).” (source)

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Coprococcus eutactus

Coprococcus eutactus:

• Abundance associated with greater bacterial gene richness in the gut • Coprococcus may be less prevalent in autistic children compared to neurotypical children; may be result of intestinal disaccharidase deficiencies common in autism • In IBS, reduced abundance reported (in association with elevated Ruminococcus spp.)

Source: https://www.gdx.net/core/interpretive-guides/GI-Effects-IG.pdf

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B. vulgatus

B. vulgatus is associated with:

• Bacteroides spp. associated with lower bacterial gene richness in the gut• Lower levels of B. vulgatus have been seen in IBS patients in comparison to healthy controls • Low relative proportions of B. vulgatus, along with high concentrations of Lactobacillus spp. observed in the microbiota of obese children when compared to lean; B. vulgatus also found under-represented in microbiota of type-2 diabetics • B. vulgatus found to be present in significantly higher numbers in stools of severely autistic children when compared to controls • While increased B. vulgatus prevalence was associated with the genotype of infants at high risk of celiac disease development, another study found that B. vulgatus was more frequently detected in controls than in patients with treated celiac disease (p<0.01)

Source – https://www.gdx.net/core/interpretive-guides/GI-Effects-IG.pdf

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