Oxalobacter formigenes metabolizes oxalates in the gut and therefore colonization with this organism may reduce the risk of calcium oxalate kidney stones with healthy levels associated with a 70% reduced risk of being a recurrent calcium-oxalate stone former.
Kidney stones aren’t the only problems that oxalates cause though. Oxalates cause methylation problems that inhibit detoxification. According to Dr. Rostenberg’s article, OXALATES AND MTHFR: UNDERSTANDING THE GUT-KIDNEY AXIS:
“oxalates create biochemical problems that make methylation issues worse. Since oxalate problems cause sulfate problems, the genes most effected will be the SULT and other phase II related pathways. The sulfate molecule is key in order for the liver to perform the daily task of detoxification. If sulfate levels drop, then the body cannot use the SULT pathway to detoxify. Instead it will be forced to use other Phase II pathways which can put greater demand on pathways that are also genetically slowed down. When we consider other slowed Phase II detoxification gene SNPs such as NAT2, ALDH, COMT, GSH, GSS, UGT, and SOUX we can begin to see that a lack of sulfate molecules can have a broad negative impact on all of our detoxification pathways.”
Dr. Rostenberg goes on to say:
“As you will soon see, when oxalate levels are high, sulfate levels drop slowing down detoxification. Low sulfate levels put extra stress into the methylation cycle to provide the body with sulfate molecules. In individuals with an impaired methylation cycle this can provoke methylation issues such as high homocysteine, developmental disorders, gallbladder dysfunction, hormone imbalances, excess inflammation, poor growth and to name but a few. So with oxalate issues and the biochemical chaos it creates, a great deal of stress is placed on the methylation cycle.”
More information about oxalates can be found through the following links:
Trying Low Oxalates Facebook Group – https://www.facebook.com/groups/TryingLowOxalates/
Information about a low-oxalate diet can be found on Low Oxalate Info: Hope and Healing on the Low Oxalate Diet.
Dr. Rostenberg’s protocol for reducing oxalates can also be found here –http://www.beyondmthfr.com/high-oxalates/. Additional information from Dr. Rostenberg can be found through the Contact page on http://www.beyondmthfr.com/.
Additional information about MTHFR and other gene mutations, and how they affect health, can be found on https://mthfrsupport.com/.
Normally present in 46–77% of healthy adults • Unique ability to metabolize oxalates in the gut • Dietary oxalate consumption generally increases O. formigenes abundance in controls, but not stone formers • Colonization with this bacteria may reduce risk of oxalate stone formation, with healthy levels associated with 70% reduced risk of being recurrent calcium-oxalate stone-former. (source)